Search results for "foreign body response"
showing 2 items of 2 documents
Sea Urchin Granuloma
2005
Sea urchin granuloma is a chronic focal response to the puncture of sea urchin spines, induced by the permanence of prickle remnants in the wound. Until recent years, it was thought to represent a foreign body reaction but, following the description, in 2001, of its several histologic forms, the spectrum of its likely pathogenetic mechanisms has widened to include the immune responses to different non-self antigens. Depending on individual reactivity, in most cases, a limited number of granulomas is observed, however numerous the punctures may be. We report a case with more than 200 lesions and a tuberculoid histologic pattern, indicative of an immune reaction.
The Foreign Body Response to an Implantable Therapeutic Reservoir in a Diabetic Rodent Model
2021
Advancements in type 1 diabetes mellitus treatments have vastly improved in recent years. The move toward a bioartificial pancreas and other fully implantable systems could help restore patient's glycemic control. However, the long-term success of implantable medical devices is often hindered by the foreign body response. Fibrous encapsulation "walls off" the implant to the surrounding tissue, impairing its functionality. In this study we aim to examine how streptozotocin-induced diabetes affects fibrous capsule formation and composition surrounding implantable drug delivery devices following subcutaneous implantation in a rodent model. After 2 weeks of implantation, the fibrous capsule sur…